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#chainkulii #kulii #kuliiCardioprotective efficacy of n-3 polyunsaturated fatty acids: role of vasoactive and vasodilator prostanoids.
Over the last decade, accumulating evidence indicates that n-3 polyunsaturated fatty acids (n-3 PUFA) exert protective actions against cardiovascular disorders. Most of these beneficial effects can be accounted for by reducing cardiovascular risk factors. However, it is becoming increasingly clear that n-3 PUFA also act directly by targeting myocardial structural and functional changes. Prostaglandin (PG) E2, which is an important mediator of cyclic AMP- and NO-dependent vasodilation, and especially that of endothelin-1, has been proposed to be a determinant of myocardial contractility. Moreover, there is growing evidence that cardioprotection in ischemic/reperfused organs could be, at least in part, mediated by cyclic nucleotide-dependent NO release. Indeed, experimental data indicate that the cardioprotective effect of n-3 PUFA may be due, at least in part, to the formation of a complex enzymatic pathway, involving cyclo-oxygenase, cyclo-oxygenase-2, cyclo-oxygenase-1-derived thromboxane synthase, and cyclo-oxygenase-2-derived prostacyclin synthase. Nitric oxide synthase activation through n-3 PUFA has been reported in experimental models and might, at least in part, be due to a simultaneous stimulation of the cyclic nucleotide-dependent NO pathway and that of NO-independent endothelium-derived hyperpolarizing factor. Finally, the inhibitory effect of n-3 PUFA on 11beta-hydroxysteroid dehydrogenase type 1 may account for their cardioprotective actions. The present review is focused on the role of vasoactive and vasodilator PG and NO and their precursors in the cardioprotective effects of n-3 PUFA.Quantifying the Clinical Effects of Combined Transthoracic and Transoesophageal Echocardiographic Defibrillation in Patients with Ventricular Fibrillation.
Cardioversion is the most effective treatment for ventricular fibrillation. We sought to determine the combined transthoracic and transoesophageal echocardiographic def
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